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Mesuximide (or methsuximide, methosuximide) is a succinimide anticonvulsant medication. It is sold as a racemate by Pfizer under the tradenames Petinutin (Switzerland)[1] and Celontin (United States).[2] The therapeutic efficacy of methosuximide is largely due to its pharmacologically active metabolite, N-desmethylmethosuximide, which has a longer half-life and attains much higher plasma levels than its parent.[3]
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Quick Facts Clinical data, AHFS/Drugs.com ...
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AHFS/Drugs.com | Consumer Drug Information |
MedlinePlus | a682028 |
Routes of administration | Oral |
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Pharmacokinetic data | |
Metabolism | Hepatic (demethylation and glucuronidation) |
Elimination half-life | 1.4–2.6 hours (mesuximide) 28–38 hours (active metabolite) |
Excretion | Renal |
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Formula | C12H13NO2 |
Molar mass | 203.237 g/mol g·mol−1 |
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Melting point | 52–54 °C (126–129 °F) |
Boiling point | 166–167 °C (331–333 °F) |
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