User:Mr. Ibrahem/Zolmitriptan
From Wikipedia, the free encyclopedia
Zolmitriptan, sold under the brand name Zomig among others, is a medication used to treat migraine attacks and cluster headaches.[3] It may also be used to prevent menstrual migraines.[3] It is used as a tablet by mouth or as a nose spray.[3]
Clinical data | |
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Trade names | Zomig, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a601129 |
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Routes of administration | By mouth, nasal spray |
Drug class | Triptan[2] |
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Pharmacokinetic data | |
Bioavailability | 40% (by mouth) |
Protein binding | 25% |
Metabolism | Liver (CYP1A2-mediated, to active metabolite) |
Elimination half-life | 3 hours |
Excretion | Kidney (65%) and fecal (35%) |
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Chemical and physical data | |
Formula | C16H21N3O2 |
Molar mass | 287.363 g·mol−1 |
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Common side effects include tingling, nausea, dry mouth, and dizziness.[2] Other side effects may include medication overuse headaches.[2] Serious side effects may include coronary vasospasm, stroke, high blood pressure, anaphylaxis, and serotonin syndrome.[2] It is unclear if use during pregnancy or breastfeeding is safe.[1][3] It is a triptan that works as a selective serotonin receptor agonist of the 1B and 1D subtypes.[2]
Zolmitriptan was patented in 1990 and approved for medical use in 1997.[4] It is avaliable as a generic medication.[3] In the United Kingdom 6 doses costs the NHS about £12 as of 2020.[3] This amount in the United States costs about 30 USD as of 2021.[5]