5α-Dihydroethisterone
Chemical compound / From Wikipedia, the free encyclopedia
5α-Dihydroethisterone (5α-DHET; developmental code name HE-3562) is an active metabolite of the formerly clinically used but now-discontinued progestin ethisterone and the experimental and never-marketed hormonal antineoplastic agent ethynylandrostanediol (HE-3235).[1][2] Its formation from its parent drugs is catalyzed by 5α-reductase in tissues that express the enzyme in high amounts like the liver, skin, hair follicles, and prostate gland.[1][2][3] 5α-DHET has significant affinity for steroid hormone receptors and may contribute importantly to the activities of its parent drugs.[1][2]
Quick Facts Clinical data, Other names ...
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Other names | HE-3562; 5α-Dihydro-17α-Ethynyltestosterone; 17α-Ethynyl-DHT; 17α-Ethynyl-5α-androstan-17β-ol-3-one; 5α,17α-Pregn-20-yn-17β-ol-3-one; Ethynylandrostanolone |
Drug class | Progestin; Progestogen; Androgen; Anabolic steroid |
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Formula | C21H30O2 |
Molar mass | 314.469 g·mol−1 |
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