Alendronic acid
Chemical compound / From Wikipedia, the free encyclopedia
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Alendronic acid, sold under the brand name Fosamax among others, is a bisphosphonate medication used to treat osteoporosis and Paget's disease of bone.[3] It is taken by mouth.[3] Use is often recommended together with vitamin D, calcium supplementation, and lifestyle changes.[3]
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Trade names | Fosamax, Binosto, others |
Other names | Alendronate, alendronate sodium (USAN US) |
AHFS/Drugs.com | Monograph |
MedlinePlus | a601011 |
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Routes of administration | By mouth |
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Bioavailability | 0.6% |
Metabolism | excreted unchanged |
Elimination half-life | 126 months |
Excretion | Kidney |
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ECHA InfoCard | 100.128.415 |
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Formula | C4H13NO7P2 |
Molar mass | 249.096 g·mol−1 |
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Common side effects (1 to 10% of patients) include constipation, abdominal pain, nausea, and acid reflux.[3] Use is not recommended during pregnancy or in those with poor kidney function.[4] Alendronic acid works by decreasing the activity of cells that break down bone.[3]
Alendronic acid was first described in 1978 and approved for medical use in the United States in 1995.[3][5] It is available as a generic medication. In 2021, it was the 94th most commonly prescribed medication in the United States, with more than 7 million prescriptions.[6][7]