Anti-topoisomerase antibodies
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Anti-topoisomerase antibodies (ATA) are autoantibodies directed against topoisomerase and found in several diseases, most importantly scleroderma. Diseases with ATA are autoimmune disease because they react with self-proteins. They are also referred to as anti-DNA topoisomerase I antibody (anti-topo I).
More information Autoantibody ...
Autoantibody | |
---|---|
Anti-Topoisomerase | |
Autoantigen Isoform | Topoisomerase I (human) |
Autoantigen gene | TOP1 |
Affected organ(s) | Dermis |
Associated Disease(s) | Scleroderma,
Systemic sclerosis |
Autoantibody Ig Class | IgG, IgA |
DR2 | |
HLA associations | DR15 |
DR16 | |
Other Susceptibility genes | lymphoid protein tyrosine phos- |
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