Aquaporin-3
Protein-coding gene in the species Homo sapiens / From Wikipedia, the free encyclopedia
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Aquaporin 3 (AQP-3) is the protein product of the human AQP3 gene.[5] It is found in the basolateral cell membrane of principal collecting duct cells and provides a pathway for water to exit these cells.[6] Aquaporin-3 is also permeable to glycerol, ammonia, urea, and hydrogen peroxide. It is expressed in various tissues including the skin, respiratory tract, and kidneys as well as various types of cancers.[7] In the kidney, aquaproin-3 is unresponsive to the antidiuretic hormone vasopressin, unlike aquaporin-2.[8] This protein is also a determinant for the GIL blood group system.[9]
Suberoylanilide hydroxamic acid (SAHA) (a HDAC inhibitor) increases expression of aquaporin-3 in normal skin cells (keratinocytes).[10]