CLCNKB
Protein-coding gene in the species Homo sapiens / From Wikipedia, the free encyclopedia
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Chloride channel Kb, also known as CLCNKB, is a protein which in humans is encoded by the CLCNKB gene.[5][6]
Quick Facts Identifiers, Aliases ...
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Aliases | CLCNKB, CLCKB, ClC-K2, ClC-Kb, chloride voltage-gated channel Kb | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 602023 MGI: 1329026 HomoloGene: 65 GeneCards: CLCNKB | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Chloride channel Kb (CLCNKB) is a member of the CLC family of voltage-gated chloride channels, which comprises at least 9 mammalian chloride channels.[7] Each is believed to have 12 transmembrane domains and intracellular N and C termini. Mutations in CLCNKB result in the autosomal recessive Type III Bartter syndrome.[8] CLCNKA and CLCNKB are closely related (94% sequence identity), tightly linked (separated by 11 kb of genomic sequence) and are both expressed in mammalian kidney.[5]