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Carbazochrome

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Carbazochrome
Structural formula of carbazochrome
Space-filling model of the carbazochrome molecule
Clinical data
Trade namesToxivenol
AHFS/Drugs.comInternational Drug Names
Routes of
administration
P/O, I/M
ATC code
Identifiers
  • [(3-Hydroxy-1-methyl-6-oxo-2,3-dihydroindol-5-ylidene)amino]urea
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.000.652 Edit this at Wikidata
Chemical and physical data
FormulaC10H12N4O3
Molar mass236.231 g·mol−1
3D model (JSmol)
  • O=C(N)N/N=C1/C=C2\C(=C/C1=O)N(CC2O)C
  • InChI=1S/C10H12N4O3/c1-14-4-9(16)5-2-6(12-13-10(11)17)8(15)3-7(5)14/h2-3,9,16H,4H2,1H3,(H3,11,13,17)/b12-6-
  • Key:XSXCZNVKFKNLPR-SDQBBNPISA-N
  (verify)

Carbazochrome is an antihemorrhagic, or hemostatic, agent that will cease blood flow by causing the aggregation and adhesion of platelets in the blood to form a platelet plug, ceasing blood flow from an open wound. It is hoped that this drug can be used in the future for preventing excessive blood flow during surgical operations and the treatment of hemorrhoids, but research on its effectiveness and the severity of possible side effects remains to be fairly inconclusive.

With troxerutin, it has been investigated for use in the treatment of hemorrhoids.[1][2]

Indications

Capillary and parenchymal hemorrhage (trauma, tonsillectomy, during surgery), intestinal bleeding, thrombocytopenic purpura.[citation needed]

Mechanism of action

Carbazochrome, the semicarbazone of adrenochrome, that interacts with α-adrenoreceptors on surface of platelets, which are coupled to Gq protein and initiate PLC IP3/DAG pathway to increase intracellular free calcium concentration with these subsequent actions:[citation needed]

References

  1. ^ Basile M, Gidaro S, Pacella M, Biffignandi PM, Gidaro GS (2001). "Parenteral troxerutin and carbazochrome combination in the treatment of post-hemorrhoidectomy status: a randomized, double-blind, placebo-controlled, phase IV study". Curr Med Res Opin. 17 (4): 256–61. doi:10.1185/030079901753403144. PMID 11922398.
  2. ^ Squadrito F, Altavilla D, Oliaro Bosso S (2000). "Double-blind, randomized clinical trial of troxerutin-carbazochrome in patients with hemorrhoids". Eur Rev Med Pharmacol Sci. 4 (1–2): 21–4. PMID 11409185.


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Carbazochrome
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