Cyclizine
Medication for motion sickness or vertigo / From Wikipedia, the free encyclopedia
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Cyclizine, sold under a number of brand names, is a medication used to treat and prevent nausea, vomiting and dizziness due to motion sickness or vertigo.[2] It may also be used for nausea after general anaesthesia or that which developed from opioid use.[2][3] It is taken by mouth, in the rectum, or injected into a vein.[3][4]
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Trade names | Marezine, Valoid, Nausicalm, others |
AHFS/Drugs.com | Consumer Drug Information |
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Routes of administration | By mouth, IM, IV |
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Metabolism | N-demethylated to inactive norcyclizine[1] |
Elimination half-life | 20 hours |
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ECHA InfoCard | 100.001.314 |
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Formula | C18H22N2 |
Molar mass | 266.388 g·mol−1 |
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Common side effects include sleepiness, dry mouth, constipation, and trouble with vision.[5] More serious side effects include low blood pressure and urinary retention.[5] It is not generally recommended in young children or those with glaucoma.[2][6] Cyclizine appears to be safe during pregnancy but has not been well studied.[7] It is in the anticholinergic and antihistamine family of medications.[3][6]
Cyclizine was discovered in 1947.[8] It is on the World Health Organization's List of Essential Medicines.[9] In the United States it is available over the counter.[6]