Dopamine receptor D4
Protein-coding gene in the species Homo sapiens / From Wikipedia, the free encyclopedia
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The dopamine receptor D4 is a dopamine D2-like G protein-coupled receptor encoded by the DRD4 gene on chromosome 11 at 11p15.5.[5]
The structure of DRD4 has been reported in complex with the antipsychotic drug nemonapride.[6]
As with other dopamine receptor subtypes, the D4 receptor is activated by the neurotransmitter dopamine. It is linked to many neurological and psychiatric conditions[7] including schizophrenia and bipolar disorder,[8] ADHD,[9][10] addictive behaviors,[11] Parkinson's disease,[12] and eating disorders such as anorexia nervosa.[13] A weak association has been drawn between DRD4 and borderline personality disorder.
It is also a target for drugs which treat schizophrenia and Parkinson's disease.[14] The D4 receptor is considered to be D2-like in which the activated receptor inhibits the enzyme adenylate cyclase, thereby reducing the intracellular concentration of the second messenger cyclic AMP.[15]