Desmetramadol
Opioid painkiller medication / From Wikipedia, the free encyclopedia
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Desmetramadol (INNTooltip International Nonproprietary Name), also known as O-desmethyltramadol (O-DSMT), is an opioid analgesic and the main active metabolite of tramadol.[2] Tramadol is demethylated by the liver enzyme CYP2D6[3] to desmetramadol in the same way as codeine, and so similarly to the variation in effects seen with codeine, individuals who have a less active form of CYP2D6 will tend to have reduced analgesic effects from tramadol. Because desmetramadol itself does not need to be metabolized to induce an analgesic effect, it can be used in individuals with low CYP2D6 activity unlike tramadol.
Quick Facts Clinical data, Other names ...
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Other names | O-Desmethyltramadol; O-DSMT; Omnitram |
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Metabolism | CYP3A4 and CYP2B6[1] |
Elimination half-life | 6-8 hours |
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Chemical and physical data | |
Formula | C15H23NO2 |
Molar mass | 249.354 g·mol−1 |
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