Dirlotapide
Chemical compound / From Wikipedia, the free encyclopedia
Dirlotapide is a drug used to treat obesity in dogs.[1] It is manufactured by Pfizer and Zoetis and marketed under the brand name Slentrol.[citation needed]
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Trade names | Slentrol |
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Routes of administration | By mouth |
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Protein binding | High[1] |
Metabolism | Liver |
Elimination half-life | 5–18 hours (increased with repeated dosing) |
Excretion | Feces, urine |
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Formula | C40H33F3N4O3 |
Molar mass | 674.724 g·mol−1 |
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It works as a gut-selective microsomal triglyceride transfer protein (MTTP or MTP) inhibitor.[2] This blocks the assembly and release of lipoproteins into the bloodstream, thereby reducing fat absorption.[medical citation needed] It also elicits a satiety signal from lipid-filled cells lining the intestine.[medical citation needed]