Chlorothiazide
Chemical compound / From Wikipedia, the free encyclopedia
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Chlorothiazide, sold under the brand name Diuril among others, is an organic compound used as a diuretic and as an antihypertensive.[1][2]
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Trade names | Diuril, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682341 |
Routes of administration | By mouth, IV |
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Pharmacokinetic data | |
Bioavailability | low |
Metabolism | Nil |
Elimination half-life | 45 to 120 minutes |
Excretion | Renal |
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ECHA InfoCard | 100.000.368 |
Chemical and physical data | |
Formula | C7H6ClN3O4S2 |
Molar mass | 295.71 g·mol−1 |
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Other names
6-Chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide-1,1-dioxide | |
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ECHA InfoCard | 100.000.368 |
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Properties | |
Melting point | 342.5–343 °C (648.5–649.4 °F; 615.6–616.1 K) |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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It is used both within the hospital setting or for personal use to manage excess fluid associated with congestive heart failure. Most often taken in pill form, it is usually taken orally once or twice a day. In the ICU setting, chlorothiazide is given to diurese a patient in addition to furosemide (Lasix). Working in a separate mechanism from furosemide and absorbed enterically as a reconstituted suspension administered through a nasogastric tube (NG tube), the two drugs potentiate one another.
It was patented in 1956 and approved for medical use in 1958.[3] It is on the World Health Organization's List of Essential Medicines.[4]