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Skeletal formula
Ball-and-stick model of isothipendyl
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
  • N,N-dimethyl-1-(10H-pyrido[3,2-b][1,4]benzothiazin-10-yl)propan-2-amine
CAS Number
PubChem CID
CompTox Dashboard (EPA)
ECHA InfoCard100.006.890 Edit this at Wikidata
Chemical and physical data
Molar mass285.41 g·mol−1
3D model (JSmol)
  • n2c1N(c3c(Sc1ccc2)cccc3)CC(N(C)C)C
  • InChI=1S/C16H19N3S/c1-12(18(2)3)11-19-13-7-4-5-8-14(13)20-15-9-6-10-17-16(15)19/h4-10,12H,11H2,1-3H3 checkY

Isothipendyl is a 1st generation H1 antagonist (antihistamine) and anticholinergic used as an antipruritic. It is nowadays[when?] scarcely used in the 1st line relief of allergies due to the anticholinergic side effect of somnolence but does have some limited use through topical application in the relief of insect bites and related itching (pruritus).

See also


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