JWH-018
Chemical compound / From Wikipedia, the free encyclopedia
Dear Wikiwand AI, let's keep it short by simply answering these key questions:
Can you list the top facts and stats about JWH-018?
Summarize this article for a 10 year old
JWH-018 (1-pentyl-3-(1-naphthoyl)indole, NA-PIMO[3] or AM-678)[4] is an analgesic chemical from the naphthoylindole family that acts as a full agonist at both the CB1 and CB2 cannabinoid receptors, with some selectivity for CB2. It produces effects in animals similar to those of tetrahydrocannabinol (THC), a cannabinoid naturally present in cannabis, leading to its use in synthetic cannabis products that in some countries are sold legally as "incense blends".[5][6][7][8][9]
Clinical data | |
---|---|
Trade names | Spice, K2 |
Routes of administration | Smoked, Oral |
Legal status | |
Legal status |
|
Identifiers | |
| |
CAS Number | |
PubChem CID | |
ChemSpider |
|
UNII | |
KEGG |
|
ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.163.574 |
Chemical and physical data | |
Formula | C24H23NO |
Molar mass | 341.454 g·mol−1 |
3D model (JSmol) | |
Solubility in water | hydrophobic, n/a mg/mL (20 °C) |
| |
| |
NY (what is this?) (verify) |
As a full agonist at both the CB1 and CB2 cannabinoid receptors, this chemical compound is classified as an analgesic medication.[10] The analgesic effects of cannabinoid ligands, mediated by CB1 receptors are well established in treatment of neuropathic pain, as well as cancer pain and arthritis.[10]
These compounds work by mimicking the body's naturally-produced endocannabinoid hormones such as 2-AG and anandamide (AEA), which are biologically active and can exacerbate or inhibit nerve signaling.[10] As the cause is poorly understood in chronic pain states, more research and development must be done before the therapeutic potential of this class of biologic compounds can be realized.[10]