ATP-binding domain of ABC transporters
Water-soluble domain of transmembrane ABC transporters / From Wikipedia, the free encyclopedia
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In molecular biology, ATP-binding domain of ABC transporters is a water-soluble domain of transmembrane ABC transporters.
Identifiers | |||||||||||
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Symbol | ABC_tran | ||||||||||
Pfam | PF00005 | ||||||||||
InterPro | IPR003439 | ||||||||||
PROSITE | PDOC00185 | ||||||||||
SCOP2 | 1b0u / SCOPe / SUPFAM | ||||||||||
TCDB | 3.A.1 | ||||||||||
OPM superfamily | 17 | ||||||||||
OPM protein | 2hyd | ||||||||||
CDD | cd00267 | ||||||||||
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ABC transporters belong to the ATP-Binding Cassette superfamily, which uses the hydrolysis of ATP to translocate a variety of compounds across biological membranes. ABC transporters are minimally constituted of two conserved regions: a highly conserved ATP binding cassette (ABC) and a less conserved transmembrane domain (TMD). These regions can be found on the same protein or on two different ones. Most ABC transporters function as a dimer and therefore are constituted of four domains, two ABC modules and two TMDs.