Meclizine
Chemical compound / From Wikipedia, the free encyclopedia
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Meclizine, sold under the brand name Bonine, among others, is an antihistamine used to treat motion sickness and dizziness (vertigo).[1] It is taken by mouth.[1] Effects generally begin in an hour and last for up to a day.[1]
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Trade names | Bonine, Antivert, others |
Other names | Meclozine |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682548 |
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Routes of administration | By mouth, under the tongue, in the cheek |
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Pharmacokinetic data | |
Metabolism | Liver |
Elimination half-life | 6 hours |
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ECHA InfoCard | 100.008.477 |
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Formula | C25H27ClN2 |
Molar mass | 390.96 g·mol−1 |
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Boiling point | 230 °C (446 °F) |
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Common side effects include sleepiness and dry mouth.[1] Serious side effects may include allergic reactions.[1] Use in pregnancy appears safe, but has not been well studied; use in breastfeeding is of unclear safety.[2] It is believed to work in part by anticholinergic and antihistamine mechanisms.[1]
Meclizine was patented in 1951 and came into medical use in 1953.[3] It is available as a generic medication and often over the counter.[1][4] In 2021, it was the 136th most commonly prescribed medication in the United States, with more than 4 million prescriptions.[5][6]