Methorphan
Group of stereoisomers / From Wikipedia, the free encyclopedia
Not to be confused with racemorphan.
Methorphan comes in two isomeric forms, each with differing pharmacology and effects:
- Dextromethorphan – An over-the-counter cough suppressant, as well as dissociative hallucinogen.
- Levomethorphan – A potent opioid analgesic that was never clinically developed; a prodrug of the powerful opioid agonist analgesic levorphanol (Levo-Dromoran).
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Formula | C18H25NO | ||
Molar mass | 271.404 g·mol−1 | ||
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Racemethorphan is the racemic mixture of both of these stereoisomers.[2] It is listed under the Single Convention on Narcotic Drugs 1961 and is therefore listed in the United States as a Controlled Substance, specifically as a Narcotic in Schedule II with an ACSCN of 9732 and an annual aggregate manufacturing quota of 3 grams in 2014.[3][4] The salts in use are the hydrobromide (free base conversion ratio 0.770) and the tartrate (0.644).