Neurophysin II
Cleavage product of the arginine vasopressin gene / From Wikipedia, the free encyclopedia
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Neurophysin II is a carrier protein with a size of 19,687.3 Da and is made up of a dimer of two virtually identical chains of amino acids. Neurophysin II is a cleavage product (formed by splitting of a compound molecule into a simpler one) of the AVP gene. It is a neurohypophysial hormone that is transported in vesicles with vasopressin, the other cleavage product, along axons, from magnocellular neurons of the hypothalamus to the posterior lobe of the pituitary. Although it is stored in neurosecretory granules with vasopressin and released with vasopressin into the bloodstream, its biological action is unclear. Neurophysin II is also known as a stimulator of prolactin secretion.
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arginine vasopressin (neurophysin II, antidiuretic hormone, diabetes insipidus, neurohypophyseal) | |||||||
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Identifiers | |||||||
Symbol | AVP | ||||||
Alt. symbols | ARVP | ||||||
NCBI gene | 551 | ||||||
HGNC | 894 | ||||||
OMIM | 192340 | ||||||
RefSeq | NM_000490 | ||||||
UniProt | P01185 | ||||||
Other data | |||||||
Locus | Chr. 20 p13 | ||||||
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