Pergolide
Dopamine agonist medication / From Wikipedia, the free encyclopedia
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Pergolide, sold under the brand name Permax and Prascend (veterinary) among others, is an ergoline-based dopamine receptor agonist used in some countries for the treatment of Parkinson's disease. Parkinson's disease is associated with reduced dopamine activity in the substantia nigra of the brain. Pergolide acts on many of the same receptors as dopamine to increase receptor activity.
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Trade names | Permax, Prascend (veterinary), others |
Other names | 8β-[(Methylthio)methyl]-6-propylergoline |
AHFS/Drugs.com | Monograph |
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Routes of administration | Oral |
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Protein binding | 90% |
Metabolism | Extensively Hepatic |
Elimination half-life | 27 hours |
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ECHA InfoCard | 100.241.322 |
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Formula | C19H26N2S |
Molar mass | 314.49 g·mol−1 |
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It was patented in 1978[3] and approved for medical use in 1989.[4] In 2007, pergolide was withdrawn from the U.S. market for human use after several published studies revealed a link between the drug and increased rates of valvular heart disease.[5] However, a veterinary form of pergolide, marketed under the trade name Prascend, is permitted for the treatment of pituitary pars intermedia dysfunction (PPID) also known as equine Cushing's syndrome (ECS) in horses.[6]