Pheniramine
Chemical compound / From Wikipedia, the free encyclopedia
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Pheniramine (trade name Avil among others) is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria. It has relatively strong sedative effects, and may sometimes be used off-label as an over-the-counter sleeping pill in a similar manner to other sedating antihistamines such as diphenhydramine. Pheniramine is also commonly found in eyedrops used for the treatment of allergic conjunctivitis.
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Routes of administration | Oral; injection (intramuscular or slow intravenous); topical (ophthalmic/nasal solution) |
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Metabolism | Hepatic hydroxylation, demethylation and glucuronidation |
Elimination half-life | 16 - 19 hrs (oral), 8 - 7 hrs (i.v.)[1] |
Excretion | Renal |
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ECHA InfoCard | 100.001.506 |
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Formula | C16H20N2 |
Molar mass | 240.350 g·mol−1 |
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It was patented in 1948.[2] Pheniramine is generally sold in combination with other medications, rather than as a stand-alone drug, although some formulations are available containing pheniramine by itself.