Phentermine/topiramate
Obesity medication / From Wikipedia, the free encyclopedia
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Phentermine/topiramate, sold under the brand name Qsymia, is a combination drug of phentermine and topiramate used to treat obesity.[1] It is used together with dietary changes and exercise.[2] If less than 3% weight loss is seen after 3 months it is recommended the medication be stopped.[2] The weight loss is modest.[3] Effects on heart related health problems or death is unclear.[2]
Combination of | |
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Phentermine | Appetite suppressant/stimulant of the amphetamine and phenethylamine class |
Topiramate | Anticonvulsant (extended release formulation is used) |
Clinical data | |
Pronunciation | /kjuːsɪˈmiːə/ kew-sim-EE-ə |
Trade names | Qsymia |
AHFS/Drugs.com | Professional Drug Facts |
Routes of administration | By mouth |
ATC code | |
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Common side effects include tingling, dizziness, trouble sleeping, and constipation.[2] Serious side effects may include suicide, abuse.[2] Use is not recommended during pregnancy.[1] Phentermine is a stimulant and appetite suppressant.[3] Topiramate is an anticonvulsant that has weight loss side effects.[3] The exact mechanism of action for both drugs is unknown.[3]
Phentermine/topiramate was approved for medical use in the United States in 2012.[2] In October 2012, approval was denied in Europe, due to concerns regarding safety.[4][5][6]