Pimozide
Chemical compound / From Wikipedia, the free encyclopedia
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Pimozide (sold under the brand name Orap) is an antipsychotic drug of the diphenylbutylpiperidine class. It was discovered at Janssen Pharmaceutica in 1963. It has a high potency compared to chlorpromazine (ratio 50-70:1). On a weight basis it is even more potent than haloperidol. It also has special neurologic indications for Tourette syndrome and resistant tics. The side effects include akathisia, tardive dyskinesia, and, more rarely, neuroleptic malignant syndrome and prolongation of the QT interval.
Quick Facts Clinical data, Trade names ...
Clinical data | |
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Trade names | Orap |
AHFS/Drugs.com | Monograph |
MedlinePlus | a686018 |
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Routes of administration | Oral |
Drug class | Typical antipsychotic |
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Bioavailability | 40-50% |
Metabolism | CYP3A4, CYP1A2 and CYP2D6 |
Elimination half-life | 55 hours (adults), 66 hours (children) |
Excretion | Urine |
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ECHA InfoCard | 100.016.520 |
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Formula | C28H29F2N3O |
Molar mass | 461.557 g·mol−1 |
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