Sodium channel protein type 8 subunit alpha also known as Nav1.6 is a membrane protein encoded by the SCN8A gene.[5][6] Nav1.6 is one sodium channel isoform and is the primary voltage-gated sodium channel at each node of Ranvier. The channels are highly concentrated in sensory and motor axons in the peripheral nervous system and cluster at the nodes in the central nervous system.[7][8][9]
Quick Facts Available structures, PDB ...
SCN8A |
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Identifiers |
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Aliases | SCN8A, CERIII, CIAT, EIEE13, MED, NaCh6, Nav1.6, PN4, sodium voltage-gated channel alpha subunit 8, BFIS5, MYOCL2, DEE13 |
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External IDs | OMIM: 600702 MGI: 103169 HomoloGene: 7927 GeneCards: SCN8A |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - Brodmann area 23
- middle temporal gyrus
- postcentral gyrus
- superior frontal gyrus
- endothelial cell
- entorhinal cortex
- prefrontal cortex
- dorsolateral prefrontal cortex
- pons
- Brodmann area 9
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| Top expressed in | - pontine nuclei
- subiculum
- cerebellar vermis
- prefrontal cortex
- primary motor cortex
- medial dorsal nucleus
- medial vestibular nucleus
- lateral geniculate nucleus
- medial geniculate nucleus
- olfactory tubercle
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| More reference expression data |
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BioGPS | |
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Wikidata |
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