Mecamylamine
Antihypertensive drug / From Wikipedia, the free encyclopedia
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Mecamylamine (INN, BAN; or mecamylamine hydrochloride (USAN); brand names Inversine, Vecamyl[1]) is a non-selective, non-competitive antagonist of the nicotinic acetylcholine receptors (nAChRs) that was introduced in the 1950s as an antihypertensive drug.[2] In the United States, it was voluntarily withdrawn from the market in 2009 but was brought to market in 2013 as Vecamyl and eventually was marketed by Turing Pharmaceuticals.[3][4]
Quick Facts Clinical data, Trade names ...
Clinical data | |
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Trade names | Inversine, Vecamyl |
AHFS/Drugs.com | Consumer Drug Information |
Routes of administration | Oral |
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Protein binding | 40% |
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ECHA InfoCard | 100.000.433 |
Chemical and physical data | |
Formula | C11H21N |
Molar mass | 167.296 g·mol−1 |
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Chemically, mecamylamine is a secondary aliphatic amine, with a pKaH of 11.2[5]