TMC8

TMC8
Identifiers
Aliases	TMC8, EV2, EVER2, EVIN2, transmembrane channel like 8
External IDs	OMIM: 605829 MGI: 2669037 HomoloGene: 45126 GeneCards: TMC8
Gene location (Human)
Chr.	Chromosome 17 (human)
End	78,142,968 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	117,683,936 bp
RNA expression pattern
	Top expressed in
	spleen; ; appendix; ; lymph node; ; blood; ; thymus; ; bone marrow cells; ; monocyte; ; superficial temporal artery; ; cancellous bone; ; thymus;
	More reference expression data
	n/a
Gene ontology
Molecular function	signaling receptor binding; GO:0001948 protein binding; ion channel activity; mechanosensitive ion channel activity;
Cellular component	cytoplasm; integral component of membrane; Golgi apparatus; nuclear membrane; extracellular exosome; endoplasmic reticulum membrane; endoplasmic reticulum; membrane; extracellular space; integral component of plasma membrane;
Biological process	negative regulation of protein oligomerization; regulation of extrinsic apoptotic signaling pathway via death domain receptors; zinc ion homeostasis; ion transport; negative regulation of protein binding; regulation of cell growth; transport; ion transmembrane transport; transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	147138
	217356
	ENSG00000167895
	ENSMUSG00000050106
	Q8IU68
	Q7TN58
	NM_152468
	NM_001195088; NM_001195089; NM_001195090; NM_181856
	NP_689681
	NP_001182017; NP_001182018; NP_001182019; NP_862904
	Wikidata
View/Edit Human	View/Edit Mouse

Transmembrane channel-like 8 is a protein which in humans is encoded by the TMC8 gene.^[5]^[6]

Function

The protein encoded by this gene is an integral membrane protein that localize to the endoplasmic reticulum and is predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 leucine zipper motifs.^[6]

Clinical significance

Mutations in the TMC8 gene are associated with epidermodysplasia verruciformis (EV), an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin.^[6]

References

Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Ramoz N, Taïeb A, Rueda LA, et al. (2000). "Evidence for a nonallelic heterogeneity of epidermodysplasia verruciformis with two susceptibility loci mapped to chromosome regions 2p21-p24 and 17q25". J. Invest. Dermatol. 114 (6): 1148–53. doi:10.1046/j.1523-1747.2000.00996.x. PMID 10844558.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Keresztes G, Mutai H, Heller S (2003). "TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins". BMC Genomics. 4 (1): 24. doi:10.1186/1471-2164-4-24. PMC 165604. PMID 12812529.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Patel AS, Karagas MR, Pawlita M, et al. (2008). "Cutaneous human papillomavirus infection, the EVER2 gene and incidence of squamous cell carcinoma: a case-control study". Int. J. Cancer. 122 (10): 2377–9. doi:10.1002/ijc.23377. PMC 2705140. PMID 18224692.
Zavattaro E, Azzimonti B, Mondini M, et al. (2008). "Identification of defective Fas function and variation of the perforin gene in an epidermodysplasia verruciformis patient lacking EVER1 and EVER2 mutations". J. Invest. Dermatol. 128 (3): 732–5. doi:10.1038/sj.jid.5701124. PMID 17960179.
Lazarczyk M, Pons C, Mendoza JA, et al. (2008). "Regulation of cellular zinc balance as a potential mechanism of EVER-mediated protection against pathogenesis by cutaneous oncogenic human papillomaviruses". J. Exp. Med. 205 (1): 35–42. doi:10.1084/jem.20071311. PMC 2234378. PMID 18158319.
Kurima K, Yang Y, Sorber K, Griffith AJ (2003). "Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis". Genomics. 82 (3): 300–8. doi:10.1016/S0888-7543(03)00154-X. PMID 12906855.
Rady PL, De Oliveira WR, He Q, et al. (2007). "Novel homozygous nonsense TMC8 mutation detected in patients with epidermodysplasia verruciformis from a Brazilian family". Br. J. Dermatol. 157 (4): 831–3. doi:10.1111/j.1365-2133.2007.08123.x. PMID 17711520. S2CID 34199539.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

TMC8

From Wikipedia, the free encyclopedia

Function

Clinical significance

References

Further reading

Suggest as cover photo

Thank you for helping!

Install Wikiwand

Don't forget to rate us

Tell your friends about Wikiwand!

Enjoying Wikiwand?

Tell your friends and spread the love:

Your preferred languages

All languages

Follow Us

Don't forget to rate us

Our magic isn't perfect

Thank you for helping!

Oh no, there's been an error