Thiaminase
Class of enzymes / From Wikipedia, the free encyclopedia
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Thiaminase is an enzyme that metabolizes or breaks down thiamine into pyrimidine and thiazole. It is an antinutrient when consumed.
Quick Facts Thiamine pyridinylase, Identifiers ...
Thiamine pyridinylase | |||||||||
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Identifiers | |||||||||
EC no. | 2.5.1.2 | ||||||||
CAS no. | 9030-35-7 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Quick Facts Aminopyrimidine aminohydrolase, Identifiers ...
Aminopyrimidine aminohydrolase | |||||||||
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Identifiers | |||||||||
EC no. | 3.5.99.2 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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The old name was "aneurinase".[1]
There are two types with different Enzyme Commission numbers:[2]
- Thiamine pyridinylase, Thiaminase I (EC 2.5.1.2, InterPro: IPR030901)
- Aminopyrimidine aminohydrolase, Thinaminase II (EC 3.5.99.2, InterPro: IPR027574, IPR004305)
- 4-amino-5-aminomethyl-2-methylpyrimidine + H2O <=> 4-amino-5-hydroxymethyl-2-methylpyrimidine + NH2+[5]
- H2O + thiamine <=> 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H+[5]
- Produced by a wide range of plants and bacteria. In these organisms, it is mainly responsible for salvage of thiamine pyrimidine from degradation products, rather than the breakdown of thiamine.[5] In bacteria, it stays inside their cells.[6]