Tropisetron
Chemical compound / From Wikipedia, the free encyclopedia
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Not to be confused with Tropanserin.
Tropisetron is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic to treat nausea and vomiting following chemotherapy, although it has been used experimentally as an analgesic in cases of fibromyalgia.[1]
Quick Facts Clinical data, Trade names ...
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Trade names | Navoban |
Other names | ICS 205-930 |
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Routes of administration | Oral, IV |
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Bioavailability | ~60–80% |
Protein binding | 71% |
Metabolism | Hepatic (CYP3A4, CYP1A2, CYP2D6) |
Elimination half-life | 6–8 hours |
Excretion | Renal, Fecal |
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Formula | C17H20N2O2 |
Molar mass | 284.359 g·mol−1 |
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It was patented in 1982 and approved for medical use in 1992.[2] It is on the World Health Organization's List of Essential Medicines.[3] It is marketed by Novartis in Europe, Australia, New Zealand, Japan, South Korea and the Philippines as Navoban, but is not available in the U.S. It is also available from Novell Pharmaceutical Laboratories and marketed in several Asian countries as Setrovel.