Ex vivo lung perfusion
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Ex vivo lung perfusion, EVLP, is a form of machine perfusion aimed at sustaining the active aerobic cellular metabolism of donor lungs outside the donor's body prior to lung transplantation. This medical preservation technique typically occurs within a specialised machine engineered to mimic the conditions of the natural circulatory system. The machine supplies the lung with perfusate and ventilates it using a protective mechanical ventilator under human body temperature. This allows the delivery of essential nutrients and oxygen to the donor lung, supporting metabolic functions and allowing for prolonged preservation up to 17 hours.[1][2] The three major EVLP protocols at present are the Toronto protocol, Lund protocol, and Organ Care System protocol.[3] These EVLP protocols can be effective in rendering initially rejected donor lungs suitable for transplantation through reassessment and damage repair, thus widening the donor lung pools.[4][5]
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