User:Mr. Ibrahem/Domperidone
From Wikipedia, the free encyclopedia
Domperidone, sold under the brand name Motilium among others, is a medication used to relieve nausea, increase the transit of food through the stomach, treat migraines, and to promote breast milk production.[1][6][7] It is taken by mouth.[8] Due to the risk of side effects, use is recommended for less than a week and it is not recommended to increase breast milk.[8][9]
Clinical data | |
---|---|
Trade names | Motilium, others |
AHFS/Drugs.com | Micromedex Detailed Consumer Information |
Pregnancy category |
|
Routes of administration | By mouth, intramuscular, rectal[1] |
Drug class | D2 receptor antagonist; Prolactin releaser |
Legal status | |
Legal status |
|
Pharmacokinetic data | |
Bioavailability | By mouth: 13–17%[1][4] Intramuscular: 90%[1] |
Protein binding | ~92%[1] |
Metabolism | Liver (CYP3A4/5) and intestinal (first-pass)[1][5] |
Metabolites | All inactive[1][5] |
Elimination half-life | 7.5 hours[1][4] |
Excretion | Feces: 66%[1] Urine: 32%[1] Breast milk: small quantities[1] |
Identifiers | |
| |
Chemical and physical data | |
Formula | C22H24ClN5O2 |
Molar mass | 425.92 g·mol−1 |
3D model (JSmol) | |
Melting point | 242.5 °C (468.5 °F) |
| |
| |
(verify) |
Common side effects include a dry mouth.[8] Other side effects include anxiety, diarrhea, and sexual dysfunction.[8] Its use is not recommended in those with heart disease due to the risk of arrhythmias and sudden cardiac arrest.[8][10] Use during breastfeeding is believed safe for the baby.[8][11] Domperidone is a peripherally selective dopamine D2 receptor antagonist.[1]
Domperidone was developed in 1974 by Janssen Pharmaceutica.[12] It is available as a generic medication.[8] In the United Kingdom a months supply costs the NHS about 3 pounds.[8] While available in many countries, it is only available in the United States under compassionate use for severe gastrointestinal motility disorders not manageable by other treatments.[1][9]