User:Mr. Ibrahem/Doxylamine
From Wikipedia, the free encyclopedia
Doxylamine is a first-generation antihistamine used for trouble sleeping and allergies.[1] Use for trouble sleeping should be short term.[1] Onset of effects is about half an hour.[1] It is also used in combination with vitamin B6 (pyridoxine) for nausea and vomiting of pregnancy.[5] It is taken by mouth.[1]
Quick Facts Clinical data, Trade names ...
Clinical data | |
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Trade names | Unisom, Vicks Formula 44 (in combination with Dextromethorphan), others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682537 |
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Routes of administration | By mouth |
Drug class | First-generation antihistamine[1] |
Legal status | |
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Pharmacokinetic data | |
Bioavailability | By mouth: 24.7%[2] Intranasal: 70.8%[2] |
Metabolism | Liver (CYP2D6, CYP1A2, CYP2C9)[3] |
Elimination half-life | 10–12 hours[3] |
Excretion | Urine (60%), feces (40%)[4] |
Identifiers | |
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Chemical and physical data | |
Formula | C17H22N2O |
Molar mass | 270.369 g·mol−1 |
3D model (JSmol) | |
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Common side effects include sleepiness.[1] Other side effects include dry mouth, urinary retention, and glaucoma.[1] Children may get restless.[1] Use in pregnancy appears safe.[6] It works by blocking H1 receptors and thus blocking the effects of histamine.[1]
Doxylamine was first described in 1948.[7] It is available as a generic medication.[1] In the United States it costs less than 10 USD for 30 tablets of 25 mg as of 2020.[8]