User:Rebekah Greenwood/Passerini reaction
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This addition reaction is one of the oldest isocyanide-based multicomponent reactions (IMCR) and was first described in 1921 by Mario Passerini in Florence, Italy.[1][2] It is typically carried out in aprotic solvents but can also be performed in ionic liquids such as water or Deep Eutectic solvents (DESs).[2] It is a third order reaction; first order in each of the reactants. The Passerini reaction is often used in combinatorial and medicinal chemistry with recent utility in green chemistry and polymer chemistry.[1][3] As isocyanides exhibit high functional group tolerance, chemoselectivity, regioselectivity, and stereoselectivity, the Passerini reaction has a wide range of synthetic applications.[1][4][5][6]
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