User:Weiffenb/NOREPINEPHRINE TRANSPORTER DRAFT
From Wikipedia, the free encyclopedia
The norepinephrine transporter (NET) is a monoamine transporter. It is responsible for the Na +/Cl --dependent reuptake of extracellular norepinephrine (NE). NET can also reuptake extracellular dopamine (DA). The reuptake of these two neurotransmitters is essential in regulating concentrations in the synaptic cleft. NETs, along with the other monoamine transporters, are the targets of many antidepressants and recreational drugs. In addition, a deficiency of NET is associated with many affective and autonomic disorders such as orthostatic intolerance and ADHD.[1][2] There is evidence that single-nucleotide polymorphisms in the NET gene (SLC6A2) may be an underlying factor in some of these disorders.[2]