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Pattern in medical radiology and histopathology / From Wikipedia, the free encyclopedia
Owl's eye appearance, also known as owl's eye sign, is a pattern used in medical research to describe cells that resemble the shape of an actual owl's eye. In histology and radiology studies, microscopes and other medical imaging are used to locate this pattern of "owl's eye" shaped cells. The presence of "owl's eye" cells has been linked to a variety of conditions, such as in the pathology of Hodgkin's lymphoma, a form of cancer. In particular, owl's eye appearance has been used to indicate the presence of cytomegalovirus (CMV), a genus of virus found in humans and other primates.
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The description "owl's eye" may refer to:
- Cells with perinuclear vacuolization around centrally located pyknotic nuclei, such as typically seen in flat warts.[1]
- The appearance of inclusion bodies within the cell, which is highly specific for cytomegalovirus infection (CMV).[2]
- The appearance of the entire nucleus, as found in Reed–Sternberg cells in individuals with Hodgkin's lymphoma.
- The appearance of the Lentiform nucleus of the basal ganglia, as seen on CT scan images of the head in individuals with cerebral hypoxia.[3]