Vanoxerine
Chemical compound / From Wikipedia, the free encyclopedia
Vanoxerine is a piperazine derivative which is a potent and selective dopamine reuptake inhibitor (DRI). Vanoxerine binds to the target site on the dopamine transporter (DAT) ~ 50 times more strongly than cocaine,[1] but simultaneously inhibits the release of dopamine. This combined effect only slightly elevates dopamine levels, giving vanoxerine only mild stimulant effects.[2] Vanoxerine has also been observed to be a potent blocker of the IKr (hERG) channel.[3] Vanoxerine also binds with nanomolar affinity to the serotonin transporter.[4]
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Other names | GBR-12909 |
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Elimination half-life | 6 hours approx |
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Formula | C28H32F2N2O |
Molar mass | 450.574 g·mol−1 |
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