α-Ketoglutaric acid
Chemical compound / From Wikipedia, the free encyclopedia
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α-Ketoglutaric acid (2-oxoglutaric acid) is a keto acid.
Quick Facts Names, Identifiers ...
Names | |
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Preferred IUPAC name
2-Oxopentanedioic acid | |
Other names
2-Ketoglutaric acid alpha-Ketoglutaric acid 2-Oxoglutaric acid Oxoglutaric acid | |
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ECHA InfoCard | 100.005.756 |
KEGG |
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MeSH | alpha-ketoglutaric+acid |
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UNII | |
CompTox Dashboard (EPA) |
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Properties | |
C5H6O5 | |
Molar mass | 146.098 g·mol−1 |
Melting point | 115 °C (239 °F; 388 K) |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Its carboxylate, α-ketoglutarate (also called 2-oxoglutarate), is an important biological compound. It is produced by deamination of glutamate, and is an intermediate in the Krebs cycle.
The term "ketoglutaric acid", when not further qualified, almost always refers to the alpha variant. β-Ketoglutaric acid varies only by the position of the ketone functional group, and is much less common.