多巴胺β羟化酶生物催化剂 / 維基百科,自由的 encyclopedia 多巴胺β羟化酶 (英語:Dopamine β-hydroxylase,简称DBH)是一种多巴胺转化为去甲肾上腺素的酶。 Dopamine is converted to norepinephrine by the enzyme dopamine β-hydroxylase. Ascorbic acid serves as a cofactor. 事实速览 多巴胺β羟化酶, 已知的結構 ...多巴胺β羟化酶已知的結構PDB直系同源搜索: PDBe RCSB PDBID列表4ZEL識別號别名DBH;, DBM, Dopamine beta-monooxygenase, dopamine beta-hydroxylase, Dopamine β-hydroxylase, ORTHYP1外部IDOMIM:609312 MGI:94864 HomoloGene:615 GeneCards:DBH EC number1.14.17.1相關疾病dopamine beta-hydroxylase deficiency[1]為以下藥物的標靶nepicastat[2]基因位置(人类)染色体9號染色體[3]基因座9q34.2起始133,636,363 bp[3]终止133,659,329 bp[3]基因位置(小鼠)染色体小鼠2号染色体[4]基因座2 A3|2 19.29 cM起始27,055,245 bp[4]终止27,073,212 bp[4]RNA表达模式查阅更多表达数据基因本體分子功能• 金屬離子結合• monooxygenase activity• oxidoreductase activity• oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen• L-ascorbic acid binding• 催化活性• dopamine beta-monooxygenase activity• copper ion binding細胞組分• 細胞質• transport vesicle membrane• integral component of membrane• chromaffin granule lumen• chromaffin granule membrane• cytoplasmic vesicle• 膜• 細胞外區域• 細胞外空間• secretory granule membrane• secretory granule lumen• 細胞內膜結合細胞器• 内质网• 微管组织中心生物學過程• response to amphetamine• 化学性突触传递• homoiothermy• leukocyte mediated immunity• visual learning• fear response• behavioral response to ethanol• locomotory behavior• regulation of extrinsic apoptotic signaling pathway• regulation of cell population proliferation• positive regulation of vasoconstriction• glucose homeostasis• 母性行为• 記憶• leukocyte migration• response to pain• blood vessel remodeling• cytokine production• 联想型学习• catecholamine biosynthetic process• dopamine catabolic process• norepinephrine biosynthetic process• octopamine biosynthetic process• positive regulation of cold-induced thermogenesisSources:Amigo / QuickGO直系同源物種人類小鼠Entrez162113166EnsemblENSG00000123454ENSMUSG00000000889UniProtP09172Q64237mRNA序列NM_000787NM_138942蛋白序列NP_000778NP_620392基因位置(UCSC)Chr 9: 133.64 – 133.66 MbChr 2: 27.06 – 27.07 MbPubMed查找[5][6]維基數據檢視/編輯人類檢視/編輯小鼠关闭 多巴胺β羟化酶是一个由四个相同亚基组成的290千道尔顿加氧酶,催化需维生素C作为辅因子[7]。
多巴胺β羟化酶 (英語:Dopamine β-hydroxylase,简称DBH)是一种多巴胺转化为去甲肾上腺素的酶。 Dopamine is converted to norepinephrine by the enzyme dopamine β-hydroxylase. Ascorbic acid serves as a cofactor. 事实速览 多巴胺β羟化酶, 已知的結構 ...多巴胺β羟化酶已知的結構PDB直系同源搜索: PDBe RCSB PDBID列表4ZEL識別號别名DBH;, DBM, Dopamine beta-monooxygenase, dopamine beta-hydroxylase, Dopamine β-hydroxylase, ORTHYP1外部IDOMIM:609312 MGI:94864 HomoloGene:615 GeneCards:DBH EC number1.14.17.1相關疾病dopamine beta-hydroxylase deficiency[1]為以下藥物的標靶nepicastat[2]基因位置(人类)染色体9號染色體[3]基因座9q34.2起始133,636,363 bp[3]终止133,659,329 bp[3]基因位置(小鼠)染色体小鼠2号染色体[4]基因座2 A3|2 19.29 cM起始27,055,245 bp[4]终止27,073,212 bp[4]RNA表达模式查阅更多表达数据基因本體分子功能• 金屬離子結合• monooxygenase activity• oxidoreductase activity• oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen• L-ascorbic acid binding• 催化活性• dopamine beta-monooxygenase activity• copper ion binding細胞組分• 細胞質• transport vesicle membrane• integral component of membrane• chromaffin granule lumen• chromaffin granule membrane• cytoplasmic vesicle• 膜• 細胞外區域• 細胞外空間• secretory granule membrane• secretory granule lumen• 細胞內膜結合細胞器• 内质网• 微管组织中心生物學過程• response to amphetamine• 化学性突触传递• homoiothermy• leukocyte mediated immunity• visual learning• fear response• behavioral response to ethanol• locomotory behavior• regulation of extrinsic apoptotic signaling pathway• regulation of cell population proliferation• positive regulation of vasoconstriction• glucose homeostasis• 母性行为• 記憶• leukocyte migration• response to pain• blood vessel remodeling• cytokine production• 联想型学习• catecholamine biosynthetic process• dopamine catabolic process• norepinephrine biosynthetic process• octopamine biosynthetic process• positive regulation of cold-induced thermogenesisSources:Amigo / QuickGO直系同源物種人類小鼠Entrez162113166EnsemblENSG00000123454ENSMUSG00000000889UniProtP09172Q64237mRNA序列NM_000787NM_138942蛋白序列NP_000778NP_620392基因位置(UCSC)Chr 9: 133.64 – 133.66 MbChr 2: 27.06 – 27.07 MbPubMed查找[5][6]維基數據檢視/編輯人類檢視/編輯小鼠关闭 多巴胺β羟化酶是一个由四个相同亚基组成的290千道尔顿加氧酶,催化需维生素C作为辅因子[7]。