核黄素激酶 - Wikiwand
For faster navigation, this Iframe is preloading the Wikiwand page for 核黄素激酶.

核黄素激酶

维基百科,自由的百科全书

riboflavin kinase
核黄素激酶
Thermoplasma acidophilum中的核黄素激酶晶体结构[1]
识别码
EC編號 2.7.1.26
CAS号 9032-82-0
数据库
IntEnz IntEnz浏览
BRENDA英语BRENDA BRENDA入口
ExPASy英语ExPASy NiceZyme浏览
KEGG KEGG入口
MetaCyc英语MetaCyc 代谢路径
PRIAM英语PRIAM_enzyme-specific_profiles 概述
PDB RCSB PDB PDBj PDBe PDBsum
基因本体 AmiGO / EGO
Riboflavin kinase
核黄素激酶
crystal structure of flavin binding to fad synthetase from thermotoga maritina
鑑定
標誌Flavokinase
PfamPF01687
InterPro英语InterProIPR015865
 SCOP英语Structural Classification of Proteins1mrz / SUPFAM
Riboflavin kinase
核黄素激酶
鑑定
標誌Riboflavin_kinase
PfamPF01687
InterPro英语InterProIPR015865

核黄素激酶(英語:riboflavin kinaseEC 2.7.1.26)是一个催化以下化学反应

ATP + 核黄素 ADP + FMN

催化的反应的底物为ATP核黄素产物ADP黄素单核苷酸(FMN)。

但是,在古菌核黄素激酶EC 2.7.1.161)中,常使用CTP而非ATP作为反应底物,催化如下反应:

CTP + 核黄素 CDP + FMN [2]

核黄素激酶也在许多细菌中发现,具有类似的功能,但存在若干数量的氨基酸不同。

反应

+ XTP →
+ XDP

结构

截止2007年底,这类酶中已有14个三级结构被解决,在PDB的登陆代码为1N051N061N071N081NB01NB91P4M1Q9S2P3M2VBS2VBT3CTA2VBU2VBV

参考文献

  1. ^ PDB 3CTA; Bonanno, J.B., Rutter, M., Bain, K.T., Mendoza, M., Romero, R., Smith, D., Wasserman, S., Sauder, J.M., Burley, S.K., Almo, S.C. Crystal structure of riboflavin kinase from Thermoplasma acidophilum. 2008. 
  2. ^ Ammelburg M, Hartmann MD, Djuranovic S, Alva V, Koretke KK, Martin J, Sauer G, Truffault V, Zeth K, Lupas AN, Coles M. A CTP-Dependent Archaeal Riboflavin Kinase Forms a Bridge in the Evolution of Cradle-Loop Barrels. Structure. 2007, 12 (12): 1577–90 [2014-01-30]. PMID 18073108. doi:10.1016/j.str.2007.09.027. (原始内容存档于2016-12-27). 

延伸阅读

  • CHASSY BM, ARSENIS C, MCCORMICK DB. THE EFFECT OF THE LENGTH OF THE SIDE CHAIN OF FLAVINS ON REACTIVITY WITH FLAVOKINASE. J. Biol. Chem. 1965, 240: 1338–40. PMID 14284745. 
  • GIRI KV, KRISHNASWAMY PR, RAO NA. Studies on plant flavokinase. Biochem. J. 1958, 70 (1): 66–71. PMC 1196627可免费查阅. PMID 13584303. 
  • KEARNEY EB. The interaction of yeast flavokinase with riboflavin analogues. J. Biol. Chem. 1952, 194 (2): 747–54. PMID 14927668. 
  • McCormick DB and Butler RC. Substrate specificity of liver flavokinase. Biochim. Biophys. Acta. 1962, 65 (2): 326–332. doi:10.1016/0006-3002(62)91051-X. 
  • Sandoval FJ, Roje S. An FMN hydrolase is fused to a riboflavin kinase homolog in plants. J. Biol. Chem. 2005, 280 (46): 38337–45. PMID 16183635. doi:10.1074/jbc.M500350200. 
  • Solovieva IM, Tarasov KV, Perumov DA. Main physicochemical features of monofunctional flavokinase from Bacillus subtilis. B. Mosc,. Biochemistry. (2): 177–81. PMID 12693963. 
  • Solovieva IM, Kreneva RA, Leak DJ, Perumov DA. The ribR gene encodes a monofunctional riboflavin kinase which is involved in regulation of the Bacillus subtilis riboflavin operon. Microbiology. Pt 1, 145: 67–73. PMID 10206712. doi:10.1099/13500872-145-1-67. 

此条目包含有源于Pfam以及InterPro的属于公有领域的文本 IPR015865

{{bottomLinkPreText}} {{bottomLinkText}}
核黄素激酶
Listen to this article