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顺乌头酸酶

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乌头酸水合酶
7ACN.jpg
结合铁-硫簇的猪顺乌头酸酶插画。按二级结构将蛋白质着色,铁原子以蓝色表示,硫原子以红色表示[1]
识别码
EC編號 4.2.1.3
CAS号 9024-25-3
数据库
IntEnz IntEnz浏览
BRENDA英语BRENDA BRENDA入口
ExPASy英语ExPASy NiceZyme浏览
KEGG KEGG入口
MetaCyc英语MetaCyc 代谢路径
PRIAM英语PRIAM_enzyme-specific_profiles 概述
PDB RCSB PDB PDBj PDBe PDBsum
基因本体 AmiGO / EGO
顺乌头酸酶家族
(乌头酸水合酶)
PDB 1aco EBI.jpg
顺乌头酸酶结构[2]
鑑定
標誌顺乌头酸酶
PfamPF00330
InterPro英语InterProIPR001030
PROSITE英语PROSITEPDOC00423
 SCOP英语Structural Classification of Proteins1aco / SUPFAM

顺乌头酸酶[3](英語:Aconitase,简称为乌头酸酶EC 4.2.1.3)是一种在三羧酸循环中催化柠檬酸通过顺乌头酸中间步骤立体专一性可逆异构化异柠檬酸的酶,这是一个非氧化还原步骤[4][5][6]

家族成员

从细菌到人类,顺乌头酸酶都可以被表达出来。人类表达以下两种同工酶

顺乌头酸酶1,可溶性
識別
符號 ACO1
替換符號 IREB1
Entrez 48
HUGO 117
OMIM 100880
RefSeq NM_002197
UniProt P21399
其他資料
EC編號 4.2.1.3
基因座 9 p21.1
顺乌头酸酶2,线粒体酶
識別
符號 ACO2
替換符號 ACONM
Entrez 50
HUGO 118
OMIM 100850
RefSeq NM_001098
UniProt Q99798
其他資料
EC編號 4.2.1.3
基因座 22 q13.2

参考文献

  1. ^ PDB 7ACN; Lauble, H.; Kennedy, M. C.; Beinert, H.; Stout, C. D. Crystal structures of aconitase with isocitrate and nitroisocitrate bound. Biochemistry. 1992, 31 (10): 2735–48. PMID 1547214. doi:10.1021/bi00125a014. 
  2. ^ PDB 1ACO; Lauble, H; Kennedy, MC; Beinert, H; Stout, CD. Crystal Structures of Aconitase with Trans-aconitate and Nitrocitrate Bound. Journal of Molecular Biology. 1994, 237 (4): 437–51. PMID 8151704. doi:10.1006/jmbi.1994.1246. 
  3. ^ [1][永久失效連結]
  4. ^ Beinert, H; Kennedy, MC. Aconitase, a two-faced protein: Enzyme and iron regulatory factor. The FASEB journal. 1993, 7 (15): 1442–9. PMID 8262329. 
  5. ^ Flint, Dennis H.; Allen, Ronda M. Iron−Sulfur Proteins with Nonredox Functions. Chemical Reviews. 1996, 96 (7): 2315–34. doi:10.1021/cr950041r. 
  6. ^ Beinert, Helmut; Kennedy, Mary Claire; Stout, C. David. Aconitase as Iron−Sulfur Protein, Enzyme, and Iron-Regulatory Protein. Chemical Reviews. 1996, 96 (7): 2335–74. doi:10.1021/cr950040z. 

深入阅读

  • Frishman, Dmitrij; Hentze, Matthias W. Conservation of Aconitase Residues Revealed by Multiple Sequence Analysis. Implications for Structure/Function Relationships. European Journal of Biochemistry. 1996, 239 (1): 197–200. PMID 8706708. doi:10.1111/j.1432-1033.1996.0197u.x. 

外部链接

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顺乌头酸酶
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