FOXP3維基百科,自由的 encyclopedia FOXP3(Forkhead box protein P3)基因,即叉头框P3基因,也称为scurfin蛋白,位于X染色体,属于FOX蛋白家族,是一种与免疫系统响应有关的转录因子[6]。 事实速览 FOXP3, 已知的結構 ...FOXP3已知的結構PDB直系同源搜索: PDBe RCSB PDBID列表3QRF、4WK8識別號别名FOXP3;, AIID, DIETER, IPEX, JM2, PIDX, XPID, forkhead box P3外部IDOMIM:300292 MGI:1891436 HomoloGene:8516 GeneCards:FOXP3 相關疾病IPEX症候群[1]基因位置(人类)染色体X染色體[2]基因座Xp11.23起始49,250,438 bp[2]终止49,270,477 bp[2]基因位置(小鼠)染色体小鼠X染色体[3]基因座X A1.1|X 3.41 cM起始7,439,883 bp[3]终止7,461,484 bp[3]RNA表达模式查阅更多表达数据基因本體分子功能• sequence-specific DNA binding• NF-kappaB binding• transcription corepressor activity• nucleic acid binding• transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding• 血浆蛋白结合• histone deacetylase binding• DNA结合转录因子活性• NFAT protein binding• histone acetyltransferase binding• 金屬離子結合• DNA结合• protein homodimerization activity• DNA-binding transcription factor activity, RNA polymerase II-specific• RNA polymerase II cis-regulatory region sequence-specific DNA binding細胞組分• 细胞核• 胞內• 細胞質• 核质• 大分子复合体生物學過程• negative regulation of cell population proliferation• negative regulation of NF-kappaB transcription factor activity• B cell homeostasis• regulation of isotype switching to IgG isotypes• myeloid cell homeostasis• negative regulation of inflammatory response• positive regulation of interleukin-4 production• regulation of immunoglobulin production• regulation of transcription by RNA polymerase II• regulation of T cell anergy• negative regulation of interleukin-6 production• tolerance induction to self antigen• regulation of transcription, DNA-templated• negative regulation of DNA-binding transcription factor activity• positive regulation of T cell tolerance induction• negative regulation of immune response• negative regulation of interferon-gamma production• tolerance induction• regulatory T cell differentiation• positive regulation of transcription, DNA-templated• negative regulation of interleukin-2 production• positive regulation of histone acetylation• negative regulation of interleukin-5 production• negative regulation of chronic inflammatory response• CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation• positive regulation of transcription by RNA polymerase II• negative regulation of activated T cell proliferation• positive regulation of gene expression• negative regulation of interleukin-4 production• negative regulation of interleukin-10 production• 腫瘤壞死因子產生的負調控• T cell homeostasis• negative regulation of CREB transcription factor activity• negative regulation of T-helper 17 cell differentiation• T细胞活化• positive regulation of immature T cell proliferation in thymus• positive regulation of regulatory T cell differentiation• negative regulation of transcription by RNA polymerase II• positive regulation of peripheral T cell tolerance induction• positive regulation of transforming growth factor beta1 production• negative regulation of transcription, DNA-templated• negative regulation of lymphocyte proliferation• negative regulation of histone acetylation• negative regulation of interleukin-17 production• response to virus• negative regulation of histone deacetylation• CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment• positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation• negative regulation of T cell proliferation• 染色体重建• cytokine production• negative regulation of T cell cytokine production• negative regulation of isotype switching to IgE isotypes• T cell receptor signaling pathway• positive regulation of T cell anergy• transcription, DNA-templated• T cell mediated immunity• negative regulation of gene expression• anatomical structure morphogenesis• regulation of Wnt signaling pathway• regulation of regulatory T cell differentiationSources:Amigo / QuickGO直系同源物種人類小鼠Entrez5094320371EnsemblENSG00000049768ENSMUSG00000039521UniProtQ9BZS1Q99JB6mRNA序列NM_001114377NM_014009NM_001199347NM_001199348NM_054039蛋白序列NP_001107849NP_054728NP_001186276NP_001186277NP_473380基因位置(UCSC)Chr X: 49.25 – 49.27 MbChr X: 7.44 – 7.46 MbPubMed查找[4][5]維基數據檢視/編輯人類檢視/編輯小鼠关闭
FOXP3(Forkhead box protein P3)基因,即叉头框P3基因,也称为scurfin蛋白,位于X染色体,属于FOX蛋白家族,是一种与免疫系统响应有关的转录因子[6]。 事实速览 FOXP3, 已知的結構 ...FOXP3已知的結構PDB直系同源搜索: PDBe RCSB PDBID列表3QRF、4WK8識別號别名FOXP3;, AIID, DIETER, IPEX, JM2, PIDX, XPID, forkhead box P3外部IDOMIM:300292 MGI:1891436 HomoloGene:8516 GeneCards:FOXP3 相關疾病IPEX症候群[1]基因位置(人类)染色体X染色體[2]基因座Xp11.23起始49,250,438 bp[2]终止49,270,477 bp[2]基因位置(小鼠)染色体小鼠X染色体[3]基因座X A1.1|X 3.41 cM起始7,439,883 bp[3]终止7,461,484 bp[3]RNA表达模式查阅更多表达数据基因本體分子功能• sequence-specific DNA binding• NF-kappaB binding• transcription corepressor activity• nucleic acid binding• transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding• 血浆蛋白结合• histone deacetylase binding• DNA结合转录因子活性• NFAT protein binding• histone acetyltransferase binding• 金屬離子結合• DNA结合• protein homodimerization activity• DNA-binding transcription factor activity, RNA polymerase II-specific• RNA polymerase II cis-regulatory region sequence-specific DNA binding細胞組分• 细胞核• 胞內• 細胞質• 核质• 大分子复合体生物學過程• negative regulation of cell population proliferation• negative regulation of NF-kappaB transcription factor activity• B cell homeostasis• regulation of isotype switching to IgG isotypes• myeloid cell homeostasis• negative regulation of inflammatory response• positive regulation of interleukin-4 production• regulation of immunoglobulin production• regulation of transcription by RNA polymerase II• regulation of T cell anergy• negative regulation of interleukin-6 production• tolerance induction to self antigen• regulation of transcription, DNA-templated• negative regulation of DNA-binding transcription factor activity• positive regulation of T cell tolerance induction• negative regulation of immune response• negative regulation of interferon-gamma production• tolerance induction• regulatory T cell differentiation• positive regulation of transcription, DNA-templated• negative regulation of interleukin-2 production• positive regulation of histone acetylation• negative regulation of interleukin-5 production• negative regulation of chronic inflammatory response• CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation• positive regulation of transcription by RNA polymerase II• negative regulation of activated T cell proliferation• positive regulation of gene expression• negative regulation of interleukin-4 production• negative regulation of interleukin-10 production• 腫瘤壞死因子產生的負調控• T cell homeostasis• negative regulation of CREB transcription factor activity• negative regulation of T-helper 17 cell differentiation• T细胞活化• positive regulation of immature T cell proliferation in thymus• positive regulation of regulatory T cell differentiation• negative regulation of transcription by RNA polymerase II• positive regulation of peripheral T cell tolerance induction• positive regulation of transforming growth factor beta1 production• negative regulation of transcription, DNA-templated• negative regulation of lymphocyte proliferation• negative regulation of histone acetylation• negative regulation of interleukin-17 production• response to virus• negative regulation of histone deacetylation• CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment• positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation• negative regulation of T cell proliferation• 染色体重建• cytokine production• negative regulation of T cell cytokine production• negative regulation of isotype switching to IgE isotypes• T cell receptor signaling pathway• positive regulation of T cell anergy• transcription, DNA-templated• T cell mediated immunity• negative regulation of gene expression• anatomical structure morphogenesis• regulation of Wnt signaling pathway• regulation of regulatory T cell differentiationSources:Amigo / QuickGO直系同源物種人類小鼠Entrez5094320371EnsemblENSG00000049768ENSMUSG00000039521UniProtQ9BZS1Q99JB6mRNA序列NM_001114377NM_014009NM_001199347NM_001199348NM_054039蛋白序列NP_001107849NP_054728NP_001186276NP_001186277NP_473380基因位置(UCSC)Chr X: 49.25 – 49.27 MbChr X: 7.44 – 7.46 MbPubMed查找[4][5]維基數據檢視/編輯人類檢視/編輯小鼠关闭