EGR-1 (skraćenica od engleskog naziva Early Growth Response protein 1 = protein odgovora na rani faktor rasta ) znan i kao ZNF268 (engleska skraćenica za protein cinkovog prsta 268) ili NGFI-A (engleska skraćenica za protein A induciran fakrorom rasta) jest protein koji je kod ljudi kodiran genom EGR1.
Kratke činjenice Dostupne strukture, PDB ...
EGR1 |
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Identifikatori |
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Aliasi | EGR1 |
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Vanjski ID-jevi | OMIM: 128990 MGI: 95295 HomoloGene: 56394 GeneCards: EGR1 |
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Ontologija gena |
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Molekularna funkcija | • vezivanje sa DNK • sequence-specific DNA binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0000975 transcription cis-regulatory region binding • vezivanje iona metala • transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding • GO:0001948, GO:0016582 vezivanje za proteine • histone acetyltransferase binding • nucleic acid binding • hemi-methylated DNA-binding • double-stranded methylated DNA binding • vezivanje iona cinka • promoter-specific chromatin binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
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Ćelijska komponenta | • nukleoplazma • jedro • citoplazma
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Biološki proces | • regulation of apoptotic process • cellular response to organic substance • GO:0009373 regulation of transcription, DNA-templated • glomerular mesangial cell proliferation • GO:1901227 negative regulation of transcription by RNA polymerase II • response to glucose • transcription by RNA polymerase II • BMP signaling pathway • transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • response to insulin • interleukin-1-mediated signaling pathway • cellular response to mycophenolic acid • T cell differentiation • type I interferon signaling pathway • positive regulation of glomerular metanephric mesangial cell proliferation • cellular response to gamma radiation • regulation of transcription from RNA polymerase II promoter in response to hypoxia • skeletal muscle cell differentiation • cellular response to heparin • regulation of protein sumoylation • negative regulation of canonical Wnt signaling pathway • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • cellular response to interleukin-8 • response to hypoxia • response to ischemia • estrous cycle • positive regulation of hormone biosynthetic process • regulation of progesterone biosynthetic process • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • GO:1901313 positive regulation of gene expression • circadian regulation of gene expression • locomotor rhythm • rhythmic process • circadian temperature homeostasis • positive regulation of neuron death • positive regulation of tau-protein kinase activity
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Izvori:Amigo / QuickGO |
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Ortolozi |
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Vrste | Čovjek | Miš |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNK) | | |
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RefSeq (bjelančevina) | | |
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Lokacija (UCSC) | Chr 5: 138.47 – 138.47 Mb | Chr 18: 34.99 – 35 Mb |
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PubMed pretraga | [3] | [4] |
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Wikipodaci |
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Zatvori
EGR-1 je transkripcijski faktor. Nazvan je i Krox-24, TIS8 i ZENK. Prvobitno je otkriven kod miševa.