Autoimmune polyendocrine syndrome type 2
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See also: Autoimmune polyendocrine syndrome type 1
Autoimmune polyendocrine syndrome type 2, a form of autoimmune polyendocrine syndrome also known as APS-II, or PAS II, is the most common form of the polyglandular failure syndromes.[2] PAS II is defined as the association between autoimmune Addison's disease and either autoimmune thyroid disease, type 1 diabetes, or both.[5] It is heterogeneous and has not been linked to one gene. Rather, individuals are at a higher risk when they carry a particular human leukocyte antigen (HLA-DQ2, HLA-DQ8 and HLA-DR4). APS-II affects women to a greater degree than men.[2]
Quick Facts Other names, Specialty ...
Autoimmune polyendocrine syndrome type 2 | |
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Other names | Schmidt's syndrome[1] |
HLA-DQ2 one of the human leukocyte antigens genotypes responsible for this condition | |
Specialty | Endocrinology |
Symptoms | Asplenia[1] |
Risk factors | Human leukocyte antigen (HLA-DQ2, HLA-DQ8 and HLA-DR4)[2] |
Diagnostic method | Ultrasound, MRI[3] |
Treatment | Thyroid-stimulating hormone[4] |
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