Bioenhancer
Substances which increase efficacy of drugs / From Wikipedia, the free encyclopedia
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Bioenhancers or biopotentiators[1] or bioavailability enhancers is a new chapter in medical science first scientifically established in 1979 after the discovery of world's first bioenhancer piperine.[2] It is a pocket friendly drug technology which reduces the destruction, wastage and elimination of several orally administered drugs inside the body.
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Definition Bioenhancers are defined as substances that increase the bioavailability leading to increased bioefficacy of active substances with which they are combined without having any pharmacological activity of their own at the dose used.[1] They may enhance bioavailability of allopathic drugs, vitamins, nutrients and toxins depending on its mechanism of action. For example, piperine increases bioavailability of several nutrients such as beta-carotene,[3] vitamin A, vitamin B6, coenzyme Q10,[4][5] drugs such as phenytoin,[6] theophylline,[7] propanolol[7] and a toxin called aflatoxin B1.[8]
Increased Bioavailabiity means increased levels of drug in the blood stream available for drug action. Increased Bioefficacy means the increased effectiveness of the drug due to increased bioavailability or due to other mechanisms.