Escitalopram
SSRI antidepressant / From Wikipedia, the free encyclopedia
Dear Wikiwand AI, let's keep it short by simply answering these key questions:
Can you list the top facts and stats about Escitalopram?
Summarize this article for a 10 year old
Escitalopram, sold under the brand names Lexapro and Cipralex, among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.[7] Escitalopram is mainly used to treat major depressive disorder and generalized anxiety disorder.[7] It is taken by mouth,[7] available commercially as an oxalate salt exclusively.
Clinical data | |
---|---|
Pronunciation | /ˌɛsəˈtæləˌpræm/ pronunciationⓘ |
Trade names | Cipralex, Lexapro, others[1] |
AHFS/Drugs.com | Monograph |
MedlinePlus | a603005 |
License data |
|
Pregnancy category |
|
Routes of administration | By mouth |
Drug class | Selective serotonin reuptake inhibitor (SSRI) |
ATC code | |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Bioavailability | 80% |
Protein binding | ~56% |
Metabolism | Liver, specifically the enzymes CYP3A4 and CYP2C19 |
Metabolites | Desmethylcitalopram, didesmethylcitalopram |
Elimination half-life | 27–32 hours |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
DrugBank |
|
ChemSpider |
|
UNII | |
KEGG | |
ChEBI | |
ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.244.188 |
Chemical and physical data | |
Formula | C20H21FN2O |
Molar mass | 324.399 g·mol−1 |
3D model (JSmol) | |
| |
| |
NY (what is this?) (verify) |
Common side effects include trouble sleeping, nausea, sexual problems, and feeling tired.[7] More serious side effects may include suicidal thoughts in people up to the age of 24 years.[7] It is unclear if use during pregnancy or breastfeeding is safe.[8] Escitalopram is the (S)-enantiomer of citalopram (which exists as a racemate), hence the name es-citalopram.[7]
Escitalopram was approved for medical use in the United States in 2002.[7] Escitalopram is rarely replaced by twice the dose of citalopram, though escitalopram is safer and more effective.[9] It is on the World Health Organization's List of Essential Medicines.[10] In 2021, it was the fifteenth most commonly prescribed medication in the United States, with more than 30 million prescriptions.[11][12]