Recombinant live vaccine
Type of vaccine / From Wikipedia, the free encyclopedia
Live recombinant vaccines are biological preparations that stimulate immune responses to a pathogen through the use of genetically modified live bacteria or viruses. These live pathogens are biologically engineered to express exogenous antigens in the cytoplasm of target cells, thereby triggering immune responses.[1] This form of vaccine combines the beneficial features of attenuated and recombinant vaccines, providing the long-lasting immunity of attenuated vaccines’ with recombinant vaccines’ genetically engineered precision and safety.[2]
Live recombinant vaccines can be administered via orally or nasally, instead of injection. Common examples of vaccines with the aforementioned route of admission include the oral polio vaccine and the nasal spray influenza vaccine.[3][4] These vaccines can stimulate mucosal immunity and eliminate adverse effects associated with injection.[5] Research and development efforts focus on enhancing live recombinant vaccines to offer heightened protection and broader coverage against various bacteria and virus serotypes.[6]