Protein P1 viljuškaste kutije jest protein koji je kod ljudi kodiran genom FOXP1 sa hromosoma 3. FOXP1 je neophodan za pravilan razvoj mozga, srca i pluća kod sisara. Član je velike porodice transkripcijskih faktora FOX.
Kratke činjenice Dostupne strukture, PDB ...
FOXP1 |
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Dostupne strukture |
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PDB | Pretraga Human UniProta: PDBe RCSB |
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Identifikatori |
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Aliasi | FOXP1 |
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Vanjski ID-jevi | OMIM: 605515 HomoloGene: 136512 GeneCards: FOXP1 |
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Ontologija gena |
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Molekularna funkcija | • metal ion binding • sequence-specific DNA binding • protein self-association • androgen receptor binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • DNA binding • GO:0001948, GO:0016582 protein binding • identical protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • chromatin binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • transcription factor binding • protein homodimerization activity • protein heterodimerization activity
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Ćelijska komponenta | • Jedro • Nukleoplazma • citoplazma
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Biološki proces | • regulation of monocyte differentiation • negative regulation of androgen receptor signaling pathway • negative regulation of B cell apoptotic process • positive regulation of endothelial cell migration • transcription, DNA-templated • response to lipopolysaccharide • regulation of defense response to bacterium • endothelial cell activation • regulation of endothelial tube morphogenesis • macrophage activation • osteoclast development • positive regulation of smooth muscle cell proliferation • T follicular helper cell differentiation • regulation of macrophage colony-stimulating factor production • regulation of tumor necrosis factor production • regulation of inflammatory response • osteoclast differentiation • monocyte activation • GO:0009373 regulation of transcription, DNA-templated • GO:0045996 negative regulation of transcription, DNA-templated • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • somatic stem cell population maintenance • GO:1901227 negative regulation of transcription by RNA polymerase II • in utero embryonic development • positive regulation of mesenchymal cell proliferation • pre-B cell differentiation • positive regulation of immunoglobulin production • heart development • skeletal muscle tissue development • motor neuron axon guidance • ventral spinal cord development • striatum development • lung development • forebrain development • immunoglobulin V(D)J recombination • response to testosterone • sarcomere organization • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • smooth muscle tissue development • positive regulation of epithelial cell proliferation • cardiac muscle cell differentiation • regulation of cardiac muscle cell proliferation • negative regulation of cell growth involved in cardiac muscle cell development • lung secretory cell differentiation • cellular response to tumor necrosis factor • innate vocalization behavior • regulation of action potential • regulation of lung goblet cell differentiation • negative regulation of lung goblet cell differentiation • cellular response to ionomycin • positive regulation of hydrogen peroxide-induced cell death • positive regulation of cardiac muscle cell differentiation • cellular response to DNA damage stimulus • negative regulation of gene expression • positive regulation of B cell receptor signaling pathway
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Izvori:Amigo / QuickGO |
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Ortolozi |
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Vrste | Čovjek | Miš |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNK) | | |
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RefSeq (bjelančevina) | | |
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Lokacija (UCSC) | Chr 3: 70.95 – 71.58 Mb | n/a |
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PubMed pretraga | [2] | n/a |
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Wikipodaci |
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Zatvori