Mikroftalmiji pridruženi transkripcijski faktor znan i kao klasa E baznog proteina heliks-petlja-heliks 32 ili bHLHe32 jest protein koji je kod ljudi kodiran genom MITF sa hromosoma 3.
Kratke činjenice Dostupne strukture, PDB ...
MITF |
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Identifikatori |
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Aliasi | MITF |
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Vanjski ID-jevi | OMIM: 156845 MGI: 104554 HomoloGene: 4892 GeneCards: MITF |
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Ontologija gena |
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Molekularna funkcija | • DNA binding • protein dimerization activity • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001948, GO:0016582 protein binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • chromatin binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • E-box binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
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Ćelijska komponenta | • Nukleoplazma • Jedro • GO:0009327 protein-containing complex
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Biološki proces | • regulation of RNA biosynthetic process • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • GO:1901227 negative regulation of transcription by RNA polymerase II • positive regulation of DNA-templated transcription, initiation • transcription, DNA-templated • multicellular organism development • GO:1901313 positive regulation of gene expression • transcription by RNA polymerase II • GO:0009373 regulation of transcription, DNA-templated • Regulacija ekspresije gena • Wnt-signalni put • Ćelijska diferencijacija • osteoclast differentiation • melanocyte differentiation • regulation of cell population proliferation • camera-type eye development • negative regulation of apoptotic process • pigmentation • canonical Wnt signaling pathway involved in negative regulation of apoptotic process • cell fate commitment • regulation of osteoclast differentiation • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • bone remodeling • GO:0034622 protein-containing complex assembly • negative regulation of cell migration
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Izvori:Amigo / QuickGO |
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Ortolozi |
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Vrste | Čovjek | Miš |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNK) | | |
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RefSeq (bjelančevina) | | |
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Lokacija (UCSC) | Chr 3: 69.74 – 69.97 Mb | Chr 6: 97.78 – 98 Mb |
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PubMed pretraga | [3] | [4] |
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Wikipodaci |
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Zatvori