5-Aminoimidazole ribotide
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5′-Phosphoribosyl-5-aminoimidazole (or aminoimidazole ribotide, AIR) is a biochemical intermediate in the formation of purine nucleotides via inosine-5-monophosphate, and hence is a building block for DNA and RNA.[1] The vitamins thiamine[2][3] and cobalamin[4] also contain fragments derived from AIR.[5] It is an intermediate in the adenine pathway and is synthesized from 5′-phosphoribosylformylglycinamidine by AIR synthetase.[6]
Quick Facts Names, Identifiers ...
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IUPAC name
1-(5-Amino-1H-imidazol-1-yl)-1-deoxy-β-D-ribofuranose 5-(dihydrogen phosphate) | |
Systematic IUPAC name
[(2R,3S,4R,5R)-5-(5-Amino-1H-imidazol-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate | |
Other names
AIR, [5-(5-amino-1-imidazolyl)-3,4-dihydroxy-2-tetrahydrofuranyl]methyl dihydrogen phosphate | |
Identifiers | |
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MeSH | aminoimidazole+ribotide |
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Properties | |
C8H14N3O7P | |
Molar mass | 295.186 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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