Brimonidine
Chemical compound / From Wikipedia, the free encyclopedia
Dear Wikiwand AI, let's keep it short by simply answering these key questions:
Can you list the top facts and stats about Brimonidine?
Summarize this article for a 10 year old
Brimonidine is an α2 agonist medication used to treat open-angle glaucoma, ocular hypertension, and rosacea.[1][2] In rosacea it improves the redness.[2] It is used as eye drops or applied to the skin.[1][2]
Clinical data | |
---|---|
Pronunciation | /brɪˈmoʊnɪdiːn/ bri-MOH-nid-een |
Trade names | Alphagan, Mirvaso, Lumify, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a601232 |
License data |
|
Pregnancy category |
|
Routes of administration | Topical |
ATC code | |
Legal status | |
Legal status |
|
Pharmacokinetic data | |
Metabolism | Primarily liver |
Elimination half-life | 3 hours (ocular), 12 hours (topical) |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
IUPHAR/BPS | |
DrugBank |
|
ChemSpider |
|
UNII | |
KEGG |
|
ChEBI | |
ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.149.042 |
Chemical and physical data | |
Formula | C11H10BrN5 |
Molar mass | 292.140 g·mol−1 |
3D model (JSmol) | |
Melting point | 252 °C (486 °F) |
| |
| |
(verify) |
Common side effects when used in the eyes include itchiness, redness, and a dry mouth.[1] Common side effects when used on the skin include redness, burning, and headaches.[2] More significant side effects may include allergic reactions and low blood pressure.[2][1] Use in pregnancy appears to be safe.[2][1] When applied to the eye it works by decreasing the amount of aqueous humor made while increasing the amount that drains from the eye.[1] When applied to the skin it works by causing blood vessels to contract.[2]
Brimonidine was patented in 1972 and came into medical use in 1996.[3] It is available as a generic medication.[4][5] In 2021, it was the 160th most commonly prescribed medication in the United States, with more than 3 million prescriptions.[6][7]