Brotizolam
Benzodiazepine / From Wikipedia, the free encyclopedia
Dear Wikiwand AI, let's keep it short by simply answering these key questions:
Can you list the top facts and stats about Brotizolam?
Summarize this article for a 10 year old
Brotizolam[3] (marketed under brand name Lendormin) is a sedative-hypnotic[4] thienotriazolodiazepine[5] drug which is a benzodiazepine analog.[6] It possesses anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties, and is considered to be similar in effect to other short-acting hypnotic benzodiazepines such as triazolam or midazolam.[7] It is used in the short-term treatment of severe insomnia. Brotizolam is a highly potent and short-acting hypnotic, with a typical dose ranging from 0.125 to 0.25 milligrams, which is rapidly eliminated with an average half-life of 4.4 hours (range 3.6–7.9 hours).[8]
Clinical data | |
---|---|
Trade names | Lendormin |
AHFS/Drugs.com | International Drug Names |
Routes of administration | Oral |
ATC code | |
Legal status | |
Legal status |
|
Pharmacokinetic data | |
Bioavailability | 48–95% |
Metabolism | Hepatic |
Elimination half-life | 4.4 hours (range, 2.6–6.9 h) |
Excretion | Renal |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
DrugBank |
|
ChemSpider |
|
UNII | |
KEGG |
|
ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.055.404 |
Chemical and physical data | |
Formula | C15H10BrClN4S |
Molar mass | 393.69 g·mol−1 |
3D model (JSmol) | |
| |
| |
NY (what is this?) (verify) |
It was patented in 1974[9] and came into medical use in 1984.[10] Brotizolam is not approved for sale in the UK, United States or Canada. It is approved for sale in the Netherlands, Germany, Spain, Belgium, Luxembourg, Austria, Portugal, Israel, Italy, Taiwan and Japan.